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. 2021 Jun 16;12:653767. doi: 10.3389/fphar.2021.653767

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Copyright © 2021 Hua, Guo, Xie, Zhu, Yan, Tao, Shang, Qian and Duan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative peak areas of potential biomarkers identified in plasma and urine in positive and negative ion modes. (C) control group; (M) model group; (POS) positive group; (ZSSH) high-dose ZSS ethanol extract group; (ZSSL) low-dose ZSS ethanol extract group; (ZSSO) ZSS oil extract group; (ZSSH + O) high-dose ZSS ethanol + oil extract group; (ZSSL + O) low-dose ZSS ethanol + oil extract group. Values are presented as the mean ± SD, n = 6. #p < 0.05, ##p < 0.01: model vs control; *p < 0.05, **p < 0.01: treatment vs model.