Table 5.
Estimated baseline and actual outcomes with access to care and difference from no care situation for South Africa 2012 (numbers rounded to nearest multiples of 5). The total of the proportions do not equal 100% due to the exclusion of U5 deaths from other causes in this table
| Congenital disorder group | Baseline Births 2012 | Outcomes with no care | Estimated outcomes with current care 2012 | Change with current care | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Still-births | U5 Deaths (CDs) | Survivors @ 5 years (disabled) | Affected births prevented | TOP | Actual births | Still-births | U5 Deaths (CDs) | Survivors @ 5 years (cured) | Survivors @ 5 years (disabled) | Affected births | Still-births | U5 deaths (CDs) | Survivors @ 5 years (cured) | Survivors @5 years (disabled) | ||
| Single-gene disorders | ||||||||||||||||
| Baseline single-gene | 5210 | 215 | 3720 | 1110 | 0 | 145 | 5065 | 205 | 2965 | 0 | 1725 | − 145 | − 10 | − 755 | 0 | 615 |
| Consanguinity increment | 230 | 35 | 160 | 30 | 0 | 10 | 220 | 35 | 120 | 0 | 60 | − 10 | 0 | − 40 | 0 | 30 |
| Oculocutaneous albinism | 290 | 0 | 0 | 275 | 0 | 0 | 290 | 0 | 0 | 0 | 275 | 0 | 0 | 0 | 0 | 0 |
| Total single gene | 5730 | 250 | 3880 | 1415 | 0 | 155 | 5575 | 240 | 3085 | 0 | 2060 | − 155 | − 10 | − 795 | 0 | 645 |
| Chromosomal disorders | ||||||||||||||||
| Down syndrome | 2125 | 105 | 1220 | 745 | 0 | 235 | 1890 | 95 | 810 | 0 | 930 | − 235 | − 10 | − 410 | 0 | 185 |
| Other trisomies | 865 | 475 | 385 | 0 | 0 | 260 | 610 | 335 | 270 | 0 | 0 | − 255 | − 140 | − 115 | 0 | 0 |
| Rare chromosomal | 855 | 75 | 505 | 260 | 0 | 155 | 700 | 60 | 360 | 0 | 265 | − 155 | − 15 | − 145 | 0 | 5 |
| Turners syndrome | 260 | 55 | 5 | 195 | 0 | 70 | 195 | 40 | 5 | 0 | 145 | − 65 | − 15 | 0 | 0 | − 50 |
| Klinefelter syndrome | 1050 | 30 | 10 | 965 | 0 | 0 | 1050 | 30 | 10 | 0 | 965 | 0 | 0 | 0 | 0 | 0 |
| Total chromosomal | 5155 | 740 | 2,125 | 2165 | 0 | 720 | 4 445 | 560 | 1455 | 0 | 2305 | − 710 | − 180 | − 670 | 0 | 140 |
| Malformations (isolated) | ||||||||||||||||
| Congenital heart disease | 3895 | 35 | 3095 | 690 | 190 | 40 | 3660 | 35 | 2005 | 910 | 620 | − 235 | 0 | − 1090 | 910 | − 70 |
| Neural tube defects | 1355 | 305 | 1000 | 40 | 270 | 200 | 885 | 180 | 565 | 0 | 130 | − 470 | − 125 | − 435 | 0 | 90 |
| Oral facial clefts | 280 | 5 | 225 | 50 | 25 | 0 | 260 | 5 | 135 | 75 | 40 | − 20 | 0 | − 90 | 75 | − 10 |
| Very severe other | 8430 | 240 | 6650 | 1395 | 0 | 465 | 7965 | 225 | 4725 | 1450 | 1380 | − 465 | − 15 | − 1925 | 1450 | − 15 |
| Less severe other | 6060 | 40 | 285 | 5475 | 0 | 80 | 5980 | 40 | 230 | 1845 | 3605 | − 80 | 0 | − 55 | 1845 | − 1870 |
| Additional conditions | 1285 | 0 | 970 | 280 | 0 | 0 | 1290 | 0 | 630 | 440 | 180 | 5 | 0 | − 340 | 440 | − 100 |
| Total malformations | 21,305 | 625 | 12,225 | 7 930 | 485 | 785 | 20,040 | 485 | 8290 | 4720 | 5955 | − 1265 | − 140 | − 3935 | 4720 | − 1975 |
| Total CDs | 32,190 | 1615 | 18,230 | 11,510 | 485 | 1660 | 30,060 | 1285 | 12,830 | 4720 | 10,320 | − 2130 | − 330 | − 5 400 | 4720 | − 1190 |
| Proportion (%) | 100% | 5% | 57% | 36% | 2% | 5% | 93% | 4% | 40% | 15% | 32% | − 7% | − 1% | − 17% | 15% | − 4% |