Fig. 3. Proposed drug transport mechanism via CH1 and the TM8/PC2 pathway during L, T, and O functional rotation based on crystal structures.

Dodecyl β-D-maltoside (DDM) and fusidic acid (FUA) are depicted as spheres (carbon, green; oxygen, red). The switch loop (magenta) and c-loop (brown) conformations are indicated in every protomer (AP access pocket, DBP deep binding pocket, CH1 channel 1). For further discussion on the mechanism see main text and Supplementary Note 1.7. PDB IDs of the displayed protomer structures: L, L^LIG1, T, T^LIG1, T^LIG-AP, O: 4DX5; L1^LIG: 4ZJL; L2^LIG: 6ZOA; T^LIG2: 6ZOF; T^LIG-DBP: 3W9I.