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. 2021 Jun 29;11:13474. doi: 10.1038/s41598-021-92948-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RRM1 expression and sensitivity to RRM1 inhibitors. A and B, mRNA expression of RNR-related genes in DMS 273 (A) and NCI-H1048 (B) cells. RRM1 (red), RRM2 (blue), and RRM2B (green) levels were normalized to glyceraldehyde 3‐phosphate dehydrogenase (GAPDH) expression. Data represent the mean ± standard deviation (SD; n = 3). (C–F), WST-8 assay with the RRM1 inhibitors COH29 (C), triapine (D), hydroxyurea (E), and gemcitabine (F). Cells were treated with the indicated inhibitors for 3 days and their viability was assessed using the WST-8 assay. Red circle: DMS 273, blue square: H1048. Data represent the mean ± SD (n = 6–10).