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. 2021 Jun 29;11:13474. doi: 10.1038/s41598-021-92948-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative immunoblot analysis of DNA damage-related proteins in RRM1-knockdown SCLC cells. siRNA-transfected SCLC cells were subjected to western blotting at the indicated time. Total proteins and phosphorylated (p-) proteins were detected using specific antibodies: RRM1, p53, p-p53 (S15), CHK1, p-CHK1 (S345), CHK2, p-CHK2 (T68), H2A.X, and γH2A.X (S139), with GAPDH as the loading control. The blots were cropped, and full-length blots are included in the Supplementary Information.