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. 2021 Jun 29;12:4028. doi: 10.1038/s41467-021-24282-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a TM domain homodimerizes with interface formed by TM2 and TM3 of each protomer. b Electrostatic surface potential representation (±5 kT e⁻¹) of MtCorB TM domain showing a cross-sectional view of the negatively charged cavity. c Close-up view of the polar residues forming the cavity. d A magnesium ion (Mg²⁺) bound in the cavity with F_o–F_c omits map contoured at 5.0σ. e π-helical turn preceding Pro114 in TM3. Highly conserved residues are highlighted in blue. f Conservation of residues in the π-helical turn from archaea to humans.