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. 2021 Jun 29;12:4028. doi: 10.1038/s41467-021-24282-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Overall structure of MtCorBΔC R235L mutant. One chain is colored by domains. b Novel domain–domain contact between TMD and CBS-pair domain. c AHB binds to CBS-pair domain and competes for Mg²⁺-ATP site. d Large conformational change in the AHB and CBS-pair domains upon Mg²⁺-ATP binding. e The apo and ATP-bound structures are similar with differences limited to the AHB and α8 helix.