Table 2.
Distribution of Comorbidities by Longitudinal Eosinophil Pattern
| Variable | Never High (N= 67,980) | Intermittently High (N= 59,894) | Persistently High (N= 20,147) |
|---|---|---|---|
| Eczemaa | |||
| No, n (%) | 49,854 (73.3) | 41,129 (68.7) | 13,647 (67.7) |
| Yes, inactive, n (%) | 12,738 (18.7) | 12,392 (20.7) | 3880 (19.3) |
| Yes, active, n (%) | 5388 (7.9) | 6373 (10.6) | 2620 (13.0) |
| Allergic rhinitisa,b | |||
| No, n (%) | 47,167 (69.4) | 38,229 (63.8) | 12,011 (59.6) |
| Yes, inactive, n (%) | 12,378 (18.2) | 12,273 (20.5) | 4197 (20.8) |
| Yes, active, n (%) | 8435 (12.4) | 9392 (15.7) | 3939 (19.6) |
| Urticaria ever, n (%) | 5659 (8.3) | 5944 (9.9) | 1969 (9.8) |
| Food allergy ever, n (%) | 1345 (2.0) | 1521 (2.5) | 679 (3.4) |
| Anaphylaxis ever, n (%) | 364 (0.5) | 427 (0.7) | 153 (0.8) |
| Aspirin sensitivity ever, n (%) | 877 (1.3) | 925 (1.5) | 229 (1.1) |
| Chronic rhinosinusitisa | |||
| No, n (%) | 60,184 (88.5) | 51,596 (86.1) | 16,990 (84.3) |
| Yes, without nasal polyps, n (%) | 7375 (10.8) | 7111 (11.9) | 2234 (11.1) |
| Yes, with nasal polyps, n (%) | 421 (0.6) | 1187 (2.0) | 923 (4.6) |
| COPD ever, n (%) | 5576 (8.2) | 5559 (9.3) | 1563 (7.8) |
| GERD ever, n (%) | 14,231 (20.9) | 13,020 (21.7) | 3587 (17.8) |
| Diabetes mellitus ever, n (%) | 8181 (12.0) | 9390 (15.7) | 2769 (13.7) |
| Osteoporosis ever, n (%) | 3365 (4.9) | 3155 (5.3) | 804 (4.0) |
| Hypertension ever, n (%) | 23,072 (33.9) | 21,395 (35.7) | 6311 (31.3) |
| Cardiovascular disease ever, n (%)b | 13,312 (19.6) | 13,274 (22.2) | 3637 (18.1) |
| Ischemic heart disease ever, n (%) | 5910 (8.7) | 6393 (10.7) | 1846 (9.2) |
| Heart failure ever, n (%) | 1324 (1.9) | 1539 (2.6) | 383 (1.9) |
| Myocardial infarction ever, n (%) | 2085 (3.1) | 2624 (4.4) | 847 (4.2) |
| CKD, stage 3–5 ever, n (%) | 5391 (7.9) | 6058 (10.1) | 1704 (8.5) |
| Anxiety/depression ever, n (%)a,b | 33,671 (49.5) | 29,179 (48.7) | 8441 (41.9) |
| Apnea ever, n (%) | 1069 (1.6) | 1136 (1.9) | 334 (1.7) |
| Pneumonia diagnosis ever, n (%) | 3572 (5.3) | 3766 (6.3) | 1135 (5.6) |
Notes: P <0.001 for tests of independence for all categories. aStandardized mean difference (SMD) >10% for comparison of never high and persistently high. bSMD >10% for comparison of intermittently high and persistently high.
Abbreviations: CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; GERD, gastroesophageal reflux disease.