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. 2021 Jun 16;11:687629. doi: 10.3389/fonc.2021.687629

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Copyright © 2021 Naipauer, García Solá, Salyakina, Rosario, Williams, Coso, Abba, Mesri and Lacunza

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genome-wide analysis of Non-coding RNAs in a cell and animal model of Kaposi’s Sarcoma. (A) Schematic representation of the mouse-KS cell and tumor model. (B) Unsupervised clustering of the host ncRNA transcriptome. (C) Multidimensional scaling plot of the host ncRNAs showing the distance of each sample from each other determined by their leading log Fold Change (FC). (D) Workflow analysis and number of DE lncRNAs in key biological comparisons that were detected by RNA-sequencing analysis of: two KSHV (+) cells, two KSHV (−) cells, six KSHV (+) tumors, two KSHV (−) tumor cells and three KSHV (−) tumors.