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. 2021 Jun 16;11:687629. doi: 10.3389/fonc.2021.687629

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Copyright © 2021 Naipauer, García Solá, Salyakina, Rosario, Williams, Coso, Abba, Mesri and Lacunza

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway analysis of DE miRNAs and their experimentally validated target (EVT) genes. (A) Schematic representation of the miRNA–mRNA pairs with significant (p < 0.05) antagonistic expression. (B–D) Chord plot illustrating the GO biological process terms and the target genes contributing to that enrichment arranged in order of their expression level in KSHV (−) tumors versus KSHV (+) tumors (B), KSHV (+) cells versus KSHV (+) tumors; for a better visualization only a fraction of the genes corresponding to the plot is shown. The full list is available in Supplementary Table 5 (C) and KSHV (−) tumor cells versus KSHV (−) tumors (D).