Table 1.
Drug-associated to miRNA-gene pairs (upper half of the table) or genes (bottom half of the table) obtained from the lncRNA-miRNA-mRNA network.
| Drug | miRNA-gene targets | Source | Drug Tested in Clinical Trials (ID) |
|---|---|---|---|
| ABACAVIR | mir19a-TNF | Pharmaco-Mir | NCT00834457 |
| BEVACIZUMAB | miR19a-IGF1 | Pharmaco-Mir | NCT00055237, NCT01296815, NCT00923936 |
| CELECOXIB | miR17-RB1 | Pharmaco-Mir | – |
| IMATINIB | miR17-PDGFRA | Pharmaco-Mir | NCT00090987 |
| OXALIPLATIN | miR19a-IGF1 | Pharmaco-Mir | – |
| SIROLIMUS | miR19a-IGF1; miR20a-MAP3K5 | Pharmaco-Mir | NCT00450320 |
| SUNITINIB | miR-128-VEGFC; miR17-PDGFRA; miR-19a-TNF; miR-20a-PDGFRA | Pharmaco-Mir | – |
| THALIDOMIDE | miR19a-TNF | Pharmaco-Mir | NCT00049296, NCT00019123 |
| BORTEZOMIB | PSMD1, RB1, NOTCH | Pharmaco-Mir | NCT01016730 |
| Drug | gene targets | Source | Drug Tested in Clinical Trials (ID) |
| CHEMBL3397300 | EGFR | DGIdb | – |
| CISPLATIN | SMARCA4, RB1, MAP3K1, EGFR | DGIdb | – |
| DAUNORUBICIN | APP | DGIdb | NCT00002093, NCT00002985, NCT00427414 |
| ENMD-2076 | PDGFR | DGIdb | – |
| ISONIAZID | TNF | DGIdb | – |
| LORLATINIB | RB1 | DGIdb | – |
| MIDOSTAURIN | PDGFRA | DGIdb | – |
| PALBOCICLIB | SMARCA4, RB1, RPS6KA3 | DGIdb | – |
| VORINSTAT | RB1 | DGIdb | – |