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. 2021 Jun 16;12:675867. doi: 10.3389/fphys.2021.675867

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Copyright © 2021 Akwaboah, Tsevi, Yamlome, Treat, Brucal-Hallare, Cordeiro and Deo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) A representative experimental AP trace in hiPSC-CM treated with 1 μM ACh. (B) Model behavior with 300% enhancement of I_KACh simulating the effects of ACh. The ACh was administered from 20–40 s followed by washout.