FIGURE 3.

Algorithmic description of the genetic algorithm (GA) protocol used in fitting the ionic currents. θ: original model chromosome; θ[i]: original model gene; N_x: chromosomal length/number of genes; m: population size; s: offspring proportion (parent-offspring ratio =  1:s); J(): loss function (SSE or RMSE); λ_a: initial population constraint; λ_b: mutation constraint; and χ: an iterable comprising lists of crossover point(s). Length(χ[i]) ∈ (0,s]. All intervals [i.e., [a, b], (a, b] or (a, b)] are uniformly distributed. Parameters belonging to these intervals were randomly drawn.