Table 4. Changes in scores on the cognitive function tests (MMSE and MoCA), TMT-B&W, and CDR.

Test		Baseline	1 Year	Change	p*
MMSE score (n=331)		18.84±5.35	18.57±6.34	-0.27±3.54	0.198
MoCA score (n=71)		16.25±6.02	16.35±6.22	0.10±2.19	0.491
TMT-B&W, seconds
	Part A: time to completion (n=318)	172.54±86.25	172.04±89.04	-0.51±54.83	0.323
	Part B: time to completion) (n=307)	269.67±58.52	273.32±51.67	3.65±51.96	0.630
CDR (global) score (n=346)		0.94±0.48	1.05±0.59	0.11±0.37	<0.001
CDR (sum of boxes) score (n=346)		5.23±2.98	5.91±3.47	0.68±1.98	<0.001

Data are mean±standard-deviation values. This analysis only included patients whose cognitive function was assessed both at baseline and 1 year.

^*Wilcoxon's signed-rank test.

CDR: Clinical Dementia Rating, MMSE: Mini-Mental State Examination, MoCA: Montreal Cognitive Assessment, TMT-B&W: Trail-Making Test–Black and White.