TABLE 2.

Outcomes and Predictors of COVID‐19 in Liver Transplantation Recipients

Study	Cohort	Outcomes in SOT and Liver Transplantation Recipients	Outcomes in Comparator Group
Pereira et al.( 72 )	90 SOT recipients, including 13 liver and 1 liver‐kidney recipient	75.6% of patients had moderate or severe disease Mortality rate of 17.8% No difference in outcomes by type of organ transplantation	N/A
May 2020
2 centers in New York City
Belli et al.( 73 )	103 liver transplantation recipients	Mortality rate of 15.0% No patient deaths reported among the 27 patients under the age of 60 years	N/A
June 2020
Multicenter European cohort
Colmenero et al.( 74 )	111 liver transplantation recipients Comparator group: matched patients from general population	Mortality rate of 18.0% No patient deaths reported in transplantation recipients under the age of 60 years Risk of severe COVID‐19 with mycophenolate (relative risk, 3.94) but not calcineurin inhibitors or everolimus	Mortality rate of 14.9%
August 2020
25 centers in Spain
Webb et al.( 76 )	151 liver transplantation recipients Comparator group: 627 patients with SARS‐CoV‐2 infection without a history of transplantation	Mortality rate of 18.5% Hospitalization in 82.1% of patients ICU admission in 28.5% of patients Increased age, serum creatinine, and nonliver cancer associated with increased mortality	Mortality rate of 26.6% Hospitalization in 75.6% of patients ICU admission in 8.3% of patients
August 2020
International registry study
Rabiee et al.( 75 )	112 liver transplantation recipients Comparator group: age‐ and sex‐matched nontransplantation patients with CLD and COVID‐19 (n = 375)	Mortality rate of 22.3% ALI in 34.6% Changes in immunosuppression not associated with ALI or mortality ALI associated with mortality and ICU admission	ALI in 47.5%
September 2020
15 centers in the United States
Becchetti et al.( 92 )	57 liver transplantation recipients	Mortality rate of 12.0% Immunosuppression reduction in 38.6% and discontinuation in 7.0% of patients, no impact on patient outcomes	N/A
June 2020
12 centers in Europe
Mansoor et al.( 77 )	126 liver transplantation recipients Comparator group: propensity score–matched (on age, race, key comorbidities) nonliver transplantation recipients	Risk of hospitalization 40.0%	Risk of hospitalization 23.0% In adjusted analysis, no difference in risk of mortality, thrombosis, and ICU requirement between liver transplantation and comparator group
September 2020
Health research network database