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. 2021 Jun 16;8:664626. doi: 10.3389/fcvm.2021.664626

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Copyright © 2021 Chen, Pan, Ding, Ruan and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiac fibroblast-specific PGC-1αKO aggravates cardiac remodeling. (A) Representative cross sections of the heart stained for Masson and quantitative analysis of the area of fibrosis (Masson staining). (B) Representative immunofluorescent staining of Col1a1 and α-SMA and quantitative analysis of immunofluorescent staining of Col1a1 and α-SMA. (C) qPCR analysis of mRNA expression levels of PGC-1α and fibrotic genes (Col1a1, Col3a1, α-SMA, TGF-β). (D) Representative Western blot and analysis of the expression of fibrotic proteins (Col1a1, α-SMA, TGF-β). N.S. indicates no significant difference. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Data represent mean ± SEM (n = 5 per group).