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. 2021 Jun 16;8:664626. doi: 10.3389/fcvm.2021.664626

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Copyright © 2021 Chen, Pan, Ding, Ruan and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiac fibroblast-specific PGC-1αKO aggravates cardiac hypertrophy. (A) Quantitative analysis of the ratio of the weight of mouse heart to body weight. (B) Representative cross sections of the heart stained for Masson and WGA. Quantitative analysis of the thickness of ventricular wall (Masson staining) and cardiomyocyte size (WGA staining). (C) qPCR analysis of mRNA expression levels of hypertrophic markers (ANP, BNP, Gata4, βMHC). N.S. indicates no significant difference. *p < 0.05, **p < 0.01. Data represent mean ± SEM (n = 5 per group).