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. 2021 Jun 16;8:664626. doi: 10.3389/fcvm.2021.664626

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Copyright © 2021 Chen, Pan, Ding, Ruan and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiac fibroblast-specific PGC-1αKO activates the oxidative stress response in the heart. (A) Representative cross sections of the heart stained for DHE. (B) Quantitative analysis of reactive oxidative stress as assessed by DHE staining. (C) Representative Western blot and analysis of the expression of iNOS. (D) qPCR analysis of the mRNA expression levels of iNOS. N.S. indicates no significant difference. *p < 0.05, **p < 0.01. Data represent mean ± SEM (n = 3–5 per group).