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. 2021 Jun 16;12:557994. doi: 10.3389/fimmu.2021.557994

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Copyright © 2021 Zhao, Wang, Wang, Dai, Wang and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of a gene expression signature of exhausted CD8+ T cells in glioma. (A) Comparisons of GET Score among classified immune phenotypes in TCGA microarray, TCGA RNA-Seq, CGGA microarray, CGGA RNA-Seq four cohorts. (B–E) The correlation between GET Score and Tumor Purity, ESTIMATE Score, Immune Score and Stromal Score in above four cohorts respectively. (F) Venn diagram exhibited the five selected genes termed as GET Signature (PDCD1, CD27, ICOS, RUNX2, CXCR6). (G, H) Comparison of the prognosis of high GET Score and low GET Score group in total TCGA and CGGA datasets. The cut-off value was defined as the median GET Score of all involved samples. (I) Functional enrichment of GO terms relating to the GET Signature.