Table 2.
Distribution of IDH status, type and grade of glioma among immune phenotypes in CGGA dataset.
| Immune-L Phenotype | Immune-M Phenotype | Immune-H Phenotype | Chi-square test (1) | |||||
|---|---|---|---|---|---|---|---|---|
| CGGA RNA-seq cohort | IDH Status | IDH MT(%) | 280 (72.0) | IDH MT(%) | 203 (51.4) | IDH MT(%) | 45 (25.3) | χ2 = 110.855; P < 0.001 |
| IDH WT (%) | 109 (28.0) | IDH WT (%) | 192 (48.6) | IDH WT (%) | 133 (74.7) | |||
| Glioma Type | Primary (%) | 314 (77.0) | Primary (%) | 249 (61.9) | Primary (%) | 85 (49.7) | χ2 = 45.058; P < 0.001 | |
| Recurrent (%) | 94 (23.0) | Recurrent (%) | 153 (38.1) | Recurrent (%) | 86 (50.3) | |||
| Glioma Grade | LGG (%) | 322 (78.9) | LGG (%) | 240 (59.9) | LGG (%) | 61 (35.7) | χ2 = 101.384; P < 0.001 | |
| GBM (%) | 86 (21.1) | GBM (%) | 161 (40.1) | GBM (%) | 110 (64.3) | |||
| CGGA microarray cohort | IDH Status | IDH MT(%) | 62 (59.6) | IDH MT(%) | 47 (52.2) | IDH MT(%) | 25 (23.8) | χ2 = 29.941; P < 0.001 |
| IDH WT (%) | 42 (40.4) | IDH WT (%) | 43 (47.8) | IDH WT (%) | 80 (76.2) | |||
| Glioma Type | Primary (%) | 92 (91.1) | Primary (%) | 83 (95.4) | Primary (%) | 88 (88.9) | χ2 = 2.625; P = 0.269 | |
| Recurrent (%) | 9 (8.9) | Recurrent (%) | 4 (4.6) | Recurrent (%) | 11 (11.1) | |||
| Glioma Grade | LGG (%) | 82 (78.1) | LGG (%) | 53 (58.9) | LGG (%) | 39 (37.9) | χ2 = 34.592; P < 0.001 | |
| GBM (%) | 23 (21.9) | GBM (%) | 38 (42.2) | GBM (%) | 64 (62.1) | |||
(1)Chi-square test was conducted to compare these differences between immune phenotypes.
IDH MT, IDH Mutant; IDH WT, IDH Wild Type; LGG, low grade glioma; GBM, glioblastoma.