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. 2021 Apr 29;35(9):4988–5006. doi: 10.1002/ptr.7131

TABLE 2.

Inhibitory activities of flavonoids 51–59 against SARS‐CoV 3CLpro and PLpro

Flavonoid Activity

4‐Hydroxyderricin

(51)

SARS‐CoV

Inhibitor

IC50 = 81.4 μM (3CLpro cell‐free)

IC50 = 50.8 μM (3CLpro cell‐based)

IC50 = 26.0 μM (PLpro)

Xanthoangelol

(52)

SARS‐CoV

Protease inhibitor

IC50 = 38.4 μM (3CLpro cell‐free)

IC50 = 5.8 μM (3CLpro cell‐based)

IC50 = 11.7 μM (PLpro)

Xanthoangelol F

(53)

SARS‐CoV

Protease inhibitor

IC50 = 34.1 μM (3CLpro cell‐free)

IC50 = 32.6 μM (3CLpro cell‐based)

IC50 = 5.6 μM (PLpro)

Xanthoangelol D

(54)

SARS‐CoV

Protease inhibitor

IC50 = 26.6 μM (3CLpro cell‐free)

IC50 = 9.3 μM (3CLpro cell‐based)

IC50 = 19.3 μM (PLpro)

Xanthoangelol E

(55)

SARS‐CoV

Protease inhibitor

IC50 = 11.4 μM (3CLpro cell‐free)

IC50 = 7.1 μM (3CLpro cell‐based)

IC50 = 1.2 μM (PLpro)

Xanthoangelol B

(56)

SARS‐CoV

Protease inhibitor

IC50 = 22.2 μM (3CLpro cell‐free)

IC50 = 8.6 μM (3CLpro cell‐based)

IC50 = 11.7 μM (PLpro)

Xanthoangelol G

(57)

SARS‐CoV

Protease inhibitor

IC50 = 129.8 μM (3CLpro cell‐free)

IC50 = NT (3CLpro cell‐based)

IC50 = 46.4 μM (PLpro)

Xanthokeistal A

(58)

SARS‐CoV

Protease inhibitor

IC50 = 44.1 μM (3CLpro cell‐free)

IC50 = 9.8 μM (3CLpro cell‐based)

IC50 = 21.1 μM (PLpro)

Isobavachalcone

(59)

SARS‐CoV

Protease inhibitor

IC50 = 39.4 μM (3CLpro cell‐free)

IC50 = 11.9 μM (3CLpro cell‐based)

IC50 = 13.0 μM (PLpro);

IC50 = 7.3 μM (PLpro)