FIGURE 2.

Serum levels of carboxypeptidase A3 correlates with clinical parameters of disease severity in COVID-19 patients.

(A) Correlation matrix representing correlation carboxypeptidase A3 or serotonin serum levels with clinical and laboratory parameters used to determine COVID-19 severity. Spearman's coefficient value r is used as correlation descriptor, and the size of each circle symbolizes correlation strength (color scale of red and blue indicates negative or positive correlation, respectively). Correlation between serum concentration of carboxypeptidase A3 and (B) blood neutrophils, (C) qSOFA, (D) C-reactive protein. Value of Spearman's correlation (r) and significant P values (P < 0.05) are shown. (E) Receiver-operator characteristics (ROC) curves of carboxypeptidase A3 (CPA3) and serotonin serum levels for the prediction of SARS-CoV-2 infection. (F) ROC curve of C-reactive protein (CRP), carboxypeptidase A3 (CPA3), serotonin, and IL-6 in the prediction of COVID-19 severity