Table 2.
Influence of demographic parameters, comorbidities, and clinical course on SARS‐CoV‐2 IgG titersa
| p value, considering time‐lapse as covariate (Model 1)b | Standardized beta coefficient (95% CI) | p value, considering time lapse and age as covariates (Model 2)b | Standardized beta coefficient (95% CI) | |
|---|---|---|---|---|
| Age | 0.0050 ** | +0.228 (+0.071 to +0.385) | / | |
| BMI | 0.012* | +0.212 (+0.049 to +0.375) | 0.0026** | +0.233 (+0.084 to +0.382) |
| Comorbidities | ||||
| Diabetes | 0.074 | +0.175 (−0.021 to +0.37) | 0.079 | +0.167 (−0.024 to +0.358) |
| Chronic kidney disease | 0.73 | +0.040 (−0.211 to +0.290) | 0.96 | +0.008 (−0.263 to +0.280) |
| Immunodeficiency | 0.063 | −0.178 (−0.374 to +0.018) | 0.032* | −0.200 (−0.388 to −0.013) |
| Clinical course | ||||
| Need for HFNC | 0.92 | −0.010 (−0.197 to +0.177) | 0.66 | +0.041 (−0.147 to +0.229) |
| Need for HFNC after propensity score weightingc | 0.93 | +0.012 (−0.228 to +0.252) | / | |
| Need for MV | 0.32 | −0.090 (−0.271 to +0.091) | 0.44 | −0.073 (−0.264 to +0.119) |
| Need for MV after propensity score weightingc | 0.62 | −0.058 (−0.175 to +0.058) | / | |
| Need for either HFNC or MV | 0.52 | −0.062 (−0.254 to +0.129) | 0.85 | −0.019 (−0.215 to +0.177) |
| Need for either HFNC or MV after propensity score weightingc | 0.83 | −0.092 (−0.302 to +0.119) | / | |
| Corticoid treatment | 0.12 | +0.120 (−0.034 to +0.275) | 0.072 | +0.137 (−0.014 to +0.288) |
| Corticoid treatment after propensity score weightingc | 0.13 | +0.140 (−0.042 to +0.322) | / |
Abbreviations: BMI, body mass index; CI, confidence interval; HFNC, high flow nasal cannula; MV, mechanical ventilation; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2.
a
Effect was evaluated on transformed values of IgG.
b
Time lapse between diagnosis and IgG measurement is analyzed as a categorical covariable, measurements being divided in five consecutive time periods.
c
The probability of receiving the intervention was calculated by logistic regression as a function of date of hospitalization, sex, age, BMI, renal function (inverse of creatinine), presence of fever, cough, dyspnea, hypertension, diabetes, and immunodeficiency.