FIGURE 3.

Overview of developments in the field of cytokine POC devices. The histogram displays the number of publications/year using the search terms (“portable” OR “point of care” OR “paper” OR “strip” OR “lateral flow” OR “disposable” OR “wearable”) AND (“cytokine”) as analyzed by Web of Science. This search found 1075 articles published with these keywords (since 2000) with a total of 28,190 citations. Displayed underneath is an approximate timeline of the most related discoveries in the context of disease related cytokine development and selected milestone cytokine POC devices. The proinflammatory role of cytokines,^{[ 154 ]} multiplex real‐time PCR detection of cytokines,^{[ 155 ]} cytokine‐mediated link between innate immunity, inflammation, and cancer,^{[ 156 ]} IL‐6 electrochemical sensor,^{[ 157 ]} IL‐6 and CRP duplex LFA,^{[ 158 ]} IFN‐γ FET sensor,^{[ 159 ]} electrochemical paper‐based cytokine biosensor^{[ 125 ]} IL‐1β, and CRP wearable sensor^{[ 160 ]}