Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 16;12:634138. doi: 10.3389/fimmu.2021.634138

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Yuan, Zhao, Chen, Liang, Long, Zhang, Chen and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The detailed mechanism of the role exosomes play in the evolution of egg-induced granuloma to liver fibrosis. (A) S. mansoni egg-derived exosomes can promote eosinophil activation, transferring LPC (lysophosphatidylcholine) to recognize TLRs (Toll-like receptors) on eosinophils, thus participating in tissue repair. (B) S. japonica egg-derived exosomes can carry sja-miR-71a, sja-miR-1 and sja-miR-2162 to modulate HSC activation, thereby participating in the process of liver fibrosis. (C) sja-miR-3096 in S. japonicum egg-derived exosomes can suppress hepatoma proliferation and migration.