Figure 3.

Impact of the macro-areas of endocrine interest in clinical practice. The metabolic macro-area is given by the sum of obesity and dyslipidemia data; the diabetes mellitus area encloses DM1 and DM2 data; the bone metabolism area collects prevalence data of male and female osteoporosis, hypoparathyroidism, and hyperparathyroidism; The sexual and gonadal area includes data on male and female infertility, LOH, PCOS, POF, severe menopausal disorders, treated male and female sexual dysfunction, early and delayed puberty, and gender dysphoria; Thyroid dysfunction area includes thyroiditis, hypothyroidism, hyperthyroidism, and malignant thyroid nodule (the prevalence of ultrasonographic nodular pathology was not considered to avoid to overestimate the problem. In fact, the most clinically significant nodules are those that are malignant on cytologic and/or histologic examination); General endocrinology area encompasses data regarding pituitary adenomas, hypopituitarism, adrenal incidentaloma, Addison’s disease, CAH, neuroendocrine tumors, ASP, MEN.