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. 2021 Jun 16;12:636731. doi: 10.3389/fimmu.2021.636731

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Copyright © 2021 De Groot, Desai, Lelias, Miah, Terry, Khan, Li, Yi, Ardito, Martin and Kishnani

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overall agreement of the four PIMA scoring algorithms as predictors of ADA status. Among the 48 IOPD subjects evaluated, 19 (40%) developed high ADA titers; this includes subjects with high and sustained antibody titers (HSAT) as well as sustained intermediate titers (SIT). The remaining 29 subjects (60%) developed low ADA titers. PIMA V1 (previously published) accurately predicted the ADA status for 56% of the IOPD subjects. Versions V2 and V3 accurately predicted 54% of subjects, thus further adjustment was explored. Adjusting for potential Treg epitopes with V3J improved accuracy to 64% of the subjects.