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. 2021 Jun 23;14(9):101158. doi: 10.1016/j.tranon.2021.101158

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© 2021 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 3 — Inhibition of autophagy led to tumor suppression in the liver. (A) Schematic illustration of the experimental procedure. Liver tumors were induced by HRAS^G12V and shp53. Atg7 shRNA (or control shRNA) was expressed in the tumor to investigate effects of Atg7 knockdown on liver cancer. (B) Gross morphology of representative livers expressing either control shRNA (shCon) and Atg7 shRNA (shAtg7–2). Livers were harvested at 5 weeks after hydrodynamic injection. (n = 10 for each group) (C) Liver weight/body weight (LW/BW) ratios of mice expressing shCon and shAtg7–2. The graph represents the mean ± SEM (n = 10 livers per group) (*, p < 0.05).