Table 2.

Differentially expressed genes of selected enriched KEGG pathways

Gene	HUVEC R.E. (log2)	HUAEC R.E. (log2)	Fold Change	P-val	FDR P-val	KEGG pathway
AKT3	5.08	6.37	−2.45	0.0026	0.0362	a, b, c, d
COL1A1	4.15	5.35	−2.30	0.0039	0.0442	a, b
COL1A2	5.05	8.87	−14.11	4.15E-5	0.0030	a, b
COL4A1	10.30	12.04	−3.35	0.0002	0.0073	a
COL4A2	11.93	13.26	−2.52	5.91E-6	0.0002	a
EDN1	7.20	8.25	−2.07	0.0006	0.0165	c, d
FLT1	8.85	9.6	−1.68	0.0017	0.0283	a, c
FLT4	6.80	5.93	1.82	0.0032	0.0403	a
GNAQ	8.96	9.56	−1.52	0.0002	0.0079	b
GNAS	6.67	7.5	−1.78	0.0018	0.0292	b
HMOX1	10.22	7.61	6.07	1.78E-7	6.33E-5	c, d
HRAS	9.63	8.71	1.88	0.0003	0.0113	a
IL6R	4.96	4.34	1.54	0.0009	0.0199	d
ITGA1	5.00	5.70	−1.63	1.39E-5	0.0015	a
ITGA3	7.52	8.53	−2.02	8.76E-5	0.0049	a
ITGA4	5.49	7.30	−3.50	0.0002	0.0093	a
ITGAV	11.71	12.74	−2.05	7.43E-7	0.0002	a, c
ITGB3	6.12	5.31	1.76	0.0029	0.0382	a, b, c
ITPR1	6.91	7.51	−1.52	0.0031	0.0393	b
LAMA2	5.44	6.84	−2.64	3.13E-8	1.63E-5	a
MAP2K6	7.37	6.53	1.79	4.90E-6	0.0007	c
MAP3K5	7.27	8.45	−2.26	0.0006	0.0167	c
MEF2A	8.42	9.35	−1.90	0.0024	0.0344	c
MKNK1	5.82	6.78	−1.94	0.0009	0.0205	d
PDGFA	9.01	9.94	−1.90	4.10E-6	0.0006	a, c
PDGFC	9.19	10.83	−3.11	6.67E-6	0.0009	a
PIK3CA	6.08	6.92	−1.79	0.0004	0.0130	a, b, c, d
PIK3CB	8.08	8.73	−1.56	0.0003	0.0115	a, b, c, d
PPP1CA	10.9	10.21	1.64	0.0012	0.0236	a, b
PPP1R12A	9.72	10.34	−1.54	7.25E-5	0.0043	a, b
PRKAA1	7.02	7.75	−1.66	5.40E-6	0.0008	c
PRKCA	4.96	4.25	1.64	0.0031	0.0396	a, d
PRKCI	8.04	8.88	−1.79	0.0003	0.0100	b
PRKG1	5.49	6.38	−1.85	0.0034	0.0412	b
RELN	5.72	7.02	−2.46	0.0004	0.0122	a
SDC1	6.95	6.06	1.85	4.30E-5	0.0031	c
SNAP23	5.60	6.43	−1.79	0.0020	0.0306	b
SOS2	8.66	9.37	−1.63	0.0010	0.0213	a
THBS1	10.68	11.63	−1.93	0.0010	0.0215	a
VCAM1	5.14	9.33	−18.23	4.71E-7	0.0001	c

Lower case letters indicate (a) focal adhesion. (b) platelet activation. (c) fluid shear stress and atherosclerosis and, (d) HIF-1 signaling, from enriched KEGG pathways.