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. 2021 Jun 24;22(2):616. doi: 10.3892/ol.2021.12877

Figure 2.

Figure 2.

LGMN is associated with the development of thyroid carcinoma. (A) Expression levels of LGMN in normal (n=337) and thyroid carcinoma (n=512) tissues. **P<0.01. (B) Overall survival rate of patients with thyroid carcinoma in high- (n=254) and low- (n=254) LGMN expression groups. (C) LGMN expression levels of patients at different stages of thyroid carcinoma. (D) mRNA expression levels of LGMN in the normal thyroid epithelial cell line (Nthy-ori3-1) and thyroid carcinoma cells (CAL-62 and SW579) were assessed by reverse transcription-quantitative PCR analysis. Experiments were performed for three biological replicates. **P<0.01. LGMN, pseudogene legumain; TPM, transcripts per million.