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. 2021 Jun 28;14:11786469211026639. doi: 10.1177/11786469211026639

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Increased IL-17A levels in mothers transfected with pCpG-MuIl17a resulted in elevated levels of kynurenine (KYN) in the dams and fetus. (a) Relative IL-17Ra and IL-17Rc mRNA levels in embryonic day 14.5 (E14.5) fetal brains derived from pCpG-mcs- or pCpG-MuIl17a gene-transfected mothers at E12.5 (N = 4-5 mice per group, 2 independent experiments). Serum (b) and placenta (c) concentrations of tryptophan (TRP) metabolites in E18.5 dams (N = 7-11 mice per group, 3 independent experiments) after pCpG-mcs or pCpG-MuIl17a gene transfection into pregnant dams on E12.5. (d) Concentrations of TRP metabolites in fetal plasma at E18.5 (N = 3-5 pooled plasma per group). (e) Schematic presentation of E18.5 fetal brain structure. Hipp, hippocampus; LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence; POa, preoptic area; St, striatum. (f and g) Concentrations of TRP metabolites were measured in fetal brain regions of subpallium (f) and pallium (g) (N = 6-9 fetus per group, 2 independent experiments). Data are presented as means ± standard error of the mean (SEM). Student’s t-test, *P < .05, **P < .01, ***P < .001, ****P < .0001, vs control mice.