Table 3.
Tryptophan metabolites in maternal serum, placenta, fetal plasma and brain following low and high dose of kynurenine (KYN) injection at E18.5.
| 3-HK | 3-HAA | AA | |
|---|---|---|---|
| Maternal serum (nM) | |||
| +PBS | 42.6 ± 5.00 | 109.6 ± 28.7 | 210.5 ± 37.5 |
| +KYN 100 mg/kg | 477.3 ± 30.0**** | 243.2 ± 39.0 | 89.8 ± 12.6*** |
| +KYN 300 mg/kg | 1034 ± 99.0****, #### | 393.8 ± 81.3 | 93.3 ± 11.7*** |
| Placenta (fmoL/mg tissue) | |||
| +PBS | 45.3 ± 7.06 | 24.7 ± 5.61 | 167.3 ± 11.5 |
| +KYN 100 mg/kg | 771.4 ± 52.4**** | 367.5 ± 58.9*** | 109.1 ± 6.20**** |
| +KYN 300 mg/kg | 860.3 ± 162.7**** | 363.8 ± 45.5*** | 90.6 ± 5.67**** |
| Fetal plasma (nM) | |||
| +PBS | 40.6 ± 3.97 | 31.6 ± 13.7 | 239.3 ± 49.8 |
| +KYN 100 mg/kg | 545.3 ± 35.9 | 405.8 ± 58.0**** | 313.6 ± 35.1 |
| +KYN 300 mg/kg | 1738 ± 420.3****, ### | 568.0 ± 135.1*** | 1038 ± 229.9***, ### |
| Fetal brain (fmoL/mg tissue) | |||
| Subpallium | |||
| +PBS | 79.0 ± 9.77 | 7.13 ± 0.83 | 21.3 ± 1.72 |
| +KYN 100 mg/kg | 285.4 ± 42.4** | 24.5 ± 2.71 | 24.6 ± 1.47 |
| +KYN 300 mg/kg | 606.8 ± 57.4****, #### | 85.4 ± 9.18****, #### | 36.3 ± 3.61***, ## |
| Pallium | |||
| +PBS | 115.3 ± 26.8 | 10.1 ± 1.13 | 15.5 ± 1.40 |
| +KYN 100 mg/kg | 363.2 ± 35.7** | 28.5 ± 6.33 | 17.5 ± 0.98 |
| +KYN 300 mg/kg | 660.6 ± 75.4****, ### | 80.2 ± 8.88****, #### | 15.5 ± 1.60 |
Data are presented as means ± standard error of the mean (SEM).
***
P < .001, ****P < .0001 versus + PBS. ##P < .01, ###P < .001, ####P < .0001 versus + KYN 100 mg/kg.