. 2021 Mar 17;246(12):1419–1434. doi: 10.1177/1535370221999812

Table 3.

Protein data bank IDs for structures of co-chaperones and Hsp70/co-chaperone complex structures.

Co-chaperone	Structure of the co-chaperone (A)	Structure of the complex with Hsp70 (B)
Bag1	1HX1^a	1HX1^a
Bag2	3D0T^b	3CQX^c
CHIP	2C2L^d	4KBQ^e
GrpE	3A6M^f (from Thermus thermophilus)1DKG^g (from E.coli)	1DKG^g
HOP	2NC9^h	1ELWⁱ
Hsp40	1XBL^j	5NRO^k
HspBP1	1XQR^l	1XQS^m
Hsp110	2QXLⁿ	3D2F^o
Hip	4J8D, 4J8E^p	4J8F^q

^aComplex of the BAG domain (residues 151-264) of BAG1M with the NBD domain (residue 5-381) of Hsc70.¹¹⁶

^bBNB domain (residues 107–189) of murine BAG2.

^cComplex of BNB domain (residues 107–189) of murine Bag2 with Hsc70 NBD domain (residues 1-381).

^dNear full length structure of CHIP (residues 25-304) from mouse.¹¹⁷

^eComplex structure contains the CHIP-TPR domain (residues 21-154) and Hsp70 lid-tail domain (residues 541-646 Δ626-638).⁸⁷

^fCrystal structure of GrpE from Thermus thermophilus HB8.¹¹⁸

^gComplex of GrpE (residues 1-197) and NBD domain of DnaK (residues 1-388) from E.coli.¹¹⁹

^hTPR2A domain (residues 220-350) of Hop.

ⁱComplex of TPR1 domain (residues 1-118) of Hop with C-terminal Hsc70 peptide(residues 625-732).⁵⁰

^jJ domain(residues 2-76) of DNAj.¹²⁰

^kComplex of J domain (residues 3-65) of Hsp40 with DnaK (residues 2–604).⁷¹

^lCrystal structure of core domain of human HspBP1.⁹⁶

^mCrystal structure of the HspBP1 core domain (residues 84-359) complexed with the lobe II of Hsp70 NBD domain (183–371 residues).⁹⁶

ⁿYeast homolog Hsp110: Sse1 (residues 2–659).¹⁰⁸

^oComplex of Yeast homolog Hsp110: Sse1p (residues 2–659 and Δ503–524) with NBD (residues 1–377) of yeast Hsp70 homolog Ssa1p.¹²¹

^pTPR domain (residues 78–247) of Hip.¹¹¹

^qComplex of TPR domain (residues 78–247) of Hip and the NBD domain (residues 1–382, point mutation D110E) of Hsp70.¹¹¹