Figure 2.
The microphysiological systems (MPS) database is Key for the development and application of MPS. (a) The NCATS-funded MPS Database is a web-based system that aggregates experimental data taken from tissue chip developers, the NCATS-funded Tissue Chip Testing Centers, the FDA and the IQ Consortium (pharmaceutical partners). These MPS data are then aggregated with preclinical and clinical data taken from a variety of databases to enable analysis and comparison. The Database contains built-in tools to enable assessment of reproducibility and transferability of MPS experimental models and platforms, while additional computational models are being developed to enable utilization of MPS experimental models to better understand disease mechanism(s), drug and compound toxicity, and PK/PD drug predictions. (A color version of this figure is available in the online journal.)
Source: Adapted from Schurdak et al. 84 CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/).
FDA: Food and Drug Administration; MPS: microphysiological systems; NCATS: National Center for Advancing Translational Sciences.