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. 2021 Jun 15;12:611673. doi: 10.3389/fimmu.2021.611673

Figure 1.

Figure 1

Deletion of IL-4Rα on B cells decreased mycobacterial burdens and lung pathology during Mtb infection. Wild-type (BALB/c), littermate controls (IL-4Rα-/lox) and B cell-specific IL-4Rα deficient mice (mb-1creIL-4Rα-/lox) were infected via aerosol inhalation with a dose of 200 CFU H37Rv. (A) Mycobacterial burdens in the lungs at 4 weeks post-infection. (B) Lung mycobacterial burden and dissemination in the spleen at 18 weeks post-infection. (C) Representative histology images of lung sections stained with H&E and iNOS at 4 and 18 weeks post-infection (Original magnification: 10X). (D, E) Quantification of lesion area and iNOS positive area in the lungs at 4 and 18 weeks post-infection. Data are shown as mean ± SEM of n = 6 mice/group and representative of two independent experiments, analysed by unpaired, student’s t-test versus littermate control, *p < 0.05, **p < 0.01 and ***p < 0.001.