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. 2021 Jun 15;12:611673. doi: 10.3389/fimmu.2021.611673

Figure 3.

Figure 3

Adoptive transfer of WT B cells in the lungs restored the pulmonary pathology in B cell-specific IL-4Rα deficient mice during Mtb infection. Formalin-fixed lung samples were stained for the H&E and iNOS expression after 18 weeks post-infection. (A) Representative histology images from all the groups and (B) quantification of lesions area and iNOS positive staining in the lungs (Original magnification: 2X). Antibody responses in the lungs of mice. (C) IgA, (D) IgG1 and (E) total IgE production in the lungs after 18 weeks of infection. (F) Tnf and Stat1 mRNA expression in flow-sorted B cells (CD3-CD19+B220+) after 18 weeks of Mtb infection. Data are shown as mean ± SEM of n = 5 mice/group, representative of two independent experiments, analysed by unpaired, student t-test versus littermate control, *p < 0.05, **p < 0.01 and ***p < 0.001.