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. 2021 Jun 18;22(2):892. doi: 10.3892/etm.2021.10324

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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SNHG11 induces proliferation and migration in TNBC through the miR-2355-5p/CBX5 axis. (A) RT-qPCR examined the overexpression efficacy of CBX5. (B and C) CCK-8 and colony formation assays assessed the viability and proliferative ability of BT-549 cells in each group. (D and E) Transwell assays assessed the migration and invasion of cells under indicated transfection. (F) The apoptosis of BT-549 cells after indicated transfection was evaluated through flow cytometric assay. (G) Western blot analysis measured the protein levels of EMT markers in each group. ^*P<0.05 and ^**P<0.01. SNHG11, small nucleolar RNA host gene 11; TNBC, triple-negative breast cancer; miR-2355-5p, microRNA-2355-5p; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; CCK-8, Cell Counting Kit-8; EMT, epithelial-mesenchymal transition; sh-, short hairpin; NC, negative control.