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. 2021 Jun 25;22(2):908. doi: 10.3892/etm.2021.10340

Figure 2.

Figure 2

CB2R deficiency enhances Iso-induced activation and affects the morphology of microglia in the hippocampus of adult mice. (A) Representative images of immunofluorescence staining for Iba1 (green) and nuclei stained in blue (white scale bar, 100 µm). (B) Quantification of Iba1 immunofluorescence staining intensity in the hippocampus. (C) Representative images of Iba1 (green) and nuclei (blue) by immunofluorescence staining (red scale bar, 10 µm). (D) Number of Iba1+ microglial branches in the hippocampus. Values are expressed as the mean ± standard error of the mean (n=6) and analyzed using two-way ANOVA, **P<0.01, #P<0.05 and ##P<0.01. CB2R, cannabinoid receptor 2; Iba1, ionized calcium-binding adaptor molecule-1; WT, wild-type; KO, knockout; Iso, isoflurane.