Table 1.
Basic demographics for a cohort of healthy controls (HC) and patients with PAH from Sheffield and Imperial, profiled for miRNA expression. Patients with systemic sclerosis (SSc) included in both the HC and PAH classification sets. Not all metrics available for all patients. For missing values, see Supplementary table 1.
| Training Set | Validation Set | |||
| HC + SSc without PH | IPAH + SSc-PAH | HC + SSc without PH | IPAH + SSc-PAH | |
| No. Sheffield samples | 14 + 7 | 23 + 11 | 7 + 3 | 11 + 7 |
| No. Imperial Samples | 8 + 0 | 8 + 0 | 4 + 0 | 4 + 0 |
| Total sample no. | 29 | 42 | 14 | 22 |
| Mean age at sampling (years) | 54.1 (14.5) | 56.5 (14.3) | 51.6 (11.7) | 57.4 (15.3) |
| Female (%) | 12 + 6 (58.1%) | 18 + 6 (57.1%) | 7 + 3 (71.4%) | 8 + 6 (63.6%) |
| Alive 5 years follow up (%) | 28 (97%) | 28 (65%) | 14 (100%) | 9 (43%) |
| WHO Functional class (1,2,3,4) | - | (0,6,33,3) | - | (0,3,17,2) |
| Patients on immunomodulatory agent at sampling | 4 | 2 | 2 | 2 |
| Mean Pulmonary Arterial Pressure (mm Hg) | 54.9 (15.6) | 49.4 (13.7) | ||
| Pulmonary vascular resistance (dynes) | 870 (488) | 753 (448) | ||
| 6 minute walk distance: Imperial only (m) | 202 (158) | 378 (59) | ||
| ISWD: Sheffield only (m) | 214 (169) | 248 (246) | ||
| Cardiac Output (L/min) | 4.8 (1.4) | 5.0 (2.0) | ||
| Mean pulmonary arterial wedge pressure (mm Hg) | 10.4 (3.8) | 10.8 (3.2) | ||
Continuous variables described as mean (standard deviation)