TABLE 2.
Interleukin-6 associations with clinical variables
| Regression coefficient (95% CI) | OR (95% CI) | p-value | |
|---|---|---|---|
| RAP mmHg | 0.50 (0.33–0.67) | <0.001 | |
| mPAP mmHg | −0.04 (−0.46–0.37) | ns | |
| PAWP mmHg | 0.17 (0.05–0.30) | 0.007 | |
| PVR Wood units | −0.24 (−0.42 – −0.06) | 0.010 | |
| Cardiac output L·min−1 | 0.08 (0.03–0.13) | 0.004 | |
| Cardiac index L·min−1·m−2 | 0.01 (−0.03–0.05) | ns | |
| Stroke volume mL | 0.00 (0.00–0.00) | ns | |
| PA compliance mL·mmHg−1 | 0.00 (−0.04–0.03) | ns | |
| Heart rate beats·min−1 | 1.17 (0.59–1.75) | <0.001 | |
| 6MWD m | −15.99 (−21.74 – −10.25) | <0.001 | |
| RV stroke work index | −0.41 (−0.81 – −0.01) | 0.042 | |
| RV power | 4.84 (1.28–8.40) | 0.008 | |
| CTD-PAH | 1.22 (1.13–1.31) | <0.001 | |
| PoPH-PAH | 1.37 (1.18–1.59) | <0.001 | |
| Dyspnoea at rest | 1.17 (1.07–1.28) | 0.001 | |
| Intravenous/subcutaneous prostacyclin | 1.08 (1.01–1.15) | 0.019 | |
All regression coefficients and odds ratios were adjusted for age and sex. Associations with p<0.0042 are significant after Bonferroni correction for multiple testing. RAP: right atrial pressure; mPAP: mean pulmonary arterial pressure; PAWP: pulmonary artery wedge pressure; PVR: pulmonary vascular resistance; PA: pulmonary arterial; 6MWD: 6-min walk distance; RV: right ventricle; CTD-PAH: connective tissue disease-associated pulmonary arterial hypertension; PoPH-PAH: portopulmonary hypertension-associated pulmonary arterial hypertension; ns: nonsignificant.