Figure 2.

YAP/TAZ is activated in profibrotic intestinal fibroblasts. (a) Primary human intestinal fibroblasts were isolated from stenotic and nonstenotic areas of intestines from CD patients. RNA sequencing and differential expression analysis were performed (corrected p value <0.05, fold change >2). (b-d) GO analysis was used to evaluate differentially expressed genes for biological process, cellular component and molecular function. (e) GSEA indicated enrichment of transcription targets of the YAP conserved signature in fibroblasts from the stenotic intestine of CD patients.