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. 2021 Jun 26;69:103452. doi: 10.1016/j.ebiom.2021.103452

Figure 4.

Figure 4

Knockdown of YAP/TAZ inhibits the expression of fibrotic genes and cell proliferation in intestinal fibroblasts. (a) The effect of YAP/TAZ knockdown on target genes and fibrotic genes in intestinal fibroblasts derived from stenotic regions of intestines from CD patients. (b) Western blot analysis was used to examine the effects of YAP/TAZ knockdown on α-SMA expression in fibroblasts isolated from stenotic intestine from CD patients. (c) Representative images of immunofluorescence staining showing the effect of intestinal fibroblasts with YAP/TAZ knockdown on α-SMA. Scale bar = 20 μm. (d) Knocking down YAP/TAZ expression changed the proliferation of CD fibroblasts, as determined by a CCK-8 assay. Statistical analyses were performed using Student's t test. Statistical differences are shown by *p<0.05, **p<0.01, ***p<0.001, and ****p<0.0001. All data shown are from three independent experiments.