Table 2.
Univariable analysis of risk factors for stenosis in CD
| Variables | Non-obstruction group | obstruction group | Univariate | Multivariate | ||
| p value | Odds Ratio | 95% CI | p value | |||
| Sex,n(%) | 0.295 a | |||||
| Male | 8(36.4) | 14(63.6) | ||||
| Female | 10(52.6) | 9(47.4) | ||||
| Age at diagnosis, n (%) | 0.181 a | |||||
| A1 | 0(0.0) | 3(100.0) | ||||
| A2 | 9(40.9) | 13(59.1) | ||||
| A3 | 9(56.3) | 7(43.7) | ||||
| Disease duration, n (%) | 0.843 a | |||||
| <10y | 12(42.9) | 16(57.1) | ||||
| ≥10y | 6(46.2) | 7(53.8) | ||||
| EIM, n(%) | 0.634 a | |||||
| No | 12(40.0) | 18(60.0) | ||||
| Yes | 6(54.5) | 5(45.5) | ||||
| Family history, n (%) | 0.456 b | |||||
| No | 17(43.6) | 22(56.4) | ||||
| Family history of CRC or IBD | 0(0.0) | 0(0.0) | ||||
| Family history of other autoimmune disease | 1(50.0) | 1(50.0) | ||||
| History of surgery, n (%) | 0.567 a | |||||
| No | 7(38.9) | 11(61.1) | ||||
| Yes | 11(47.8) | 12(52.2) | ||||
| Location of CD, n (%) | 0.414 a | |||||
| L1 | 10(47.6) | 11(52.4) | ||||
| L2 | 2(28.6) | 5(71.4) | ||||
| L3 | 6(54.5) | 5(45.5) | ||||
| L4 | 0(0.0) | 2(100.0) | ||||
| Mesalamine, n (%) | 0.923 a | |||||
| No | 6(42.9) | 8(57.1) | ||||
| Yes | 12(44.4) | 15(55.6) | ||||
| Steroids, n (%) | 0.632 a | |||||
| No | 13(46.4) | 15(53.6) | ||||
| Yes | 5(38.5) | 8(61.5) | ||||
| Immunomodulators, n (%) | 0.447 a | |||||
| No | 13(48.1) | 14(51.9) | ||||
| Yes | 5(35.7) | 9(64.3) | ||||
| Biologics, n (%) | 0.815 a | |||||
| No | 14(46.7) | 16(53.3) | ||||
| Yes | 4(36.4) | 7(63.6) | ||||
| Hb, n (%) | 0.702 a | |||||
| ≥90g/L | 17(44.7) | 21(55.3) | ||||
| <90g/L | 1(33.3) | 2(66.7) | ||||
| Alb, n (%) | 0.397 a | |||||
| ≥35g/L | 11(50.0) | 11(50.0) | ||||
| <35g/L | 7(36.8) | 12(63.2) | ||||
| Expression of YAP, n (%) | 0.004 a | 6.796 | (1.539-30.011) | 0.011 | ||
| High expression | 6(25.0) | 18(75.0) | ||||
| Low expression | 12(70.6) | 5(29.4) | ||||
| Expression of TAZ, n (%) | 0.050 a | 3.244 | (0.777-13.549) | 0.107 | ||
| High expression | 7 (30.4) | 16 (69.6) | ||||
| Low expression | 11 (61.1) | 7 (38.9) | ||||
| Expresison of ROCK1, n (%) | 0.004 a | 5.588 | (1.308-23.879) | 0.020 | ||
| High expression | 6(25.0) | 18(75.0) | ||||
| Low expression | 12(70.6) | 5(29.4) | ||||
a, Chi-squared; b, Fisher's exact test; CI, Confidence interval; CRC, Colorectal cancer; IBD, Inflammatory bowel disease; Hb, hemoglobin; Alb, Albumin. EIM: Extraintestinal manifestation.