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. Author manuscript; available in PMC: 2022 Mar 5.
Published in final edited form as: Circ Res. 2020 Dec 30;128(5):619–635. doi: 10.1161/CIRCRESAHA.120.317768

Figure 6.

Figure 6.

A. Original 2-dimensional images from 1-Hz (P1) and 3-Hz (P3) conditioned and P3+AIP atrial cardiomyocytes (CMs) after immunostaining for NPC, T-CaMKIIδ, p-CaMKIIδ (Thr287) and HDAC4. B. Mean ± SEM of p-CaMKIIδ/T-CaMKIIδ and HDAC4[nuc] /HDAC4[cyto] ratios, with and without the cell-permeable CaMKII-inhibitor AIP. P-values in black reflect P1 vs. P3, P-values in blue reflect Control vs. AIP based on multilevel mixed effects models (n/N=CMs/dogs). C. Immunoblots and quantification of HDAC4 in subcellular fractions and nuclear/non-nuclear ratio from human atrial samples. P-values reflect control (CTL) vs. chronic AF (cAF) based on Mann Whitney test. Histone H3 and GAPDH were loading controls.