Fig. 2.

LPLA₂ inhibition in relation to the physical properties of compounds previously associated with phospholipidosis. The test compounds listed in Table 1 are graphed in relation to pKa (basic) and ClogP. The exclusion limits of the Ploemen and modified Ploemen models are delineated by the red lines. The IC₅₀s for LPLA₂-dependent 1-O-acyl N-acetylsphingosine synthase activity are indicated as follows: greater than 1 mM (red circles), less than 100 μM (green circles), greater than 100 μM and less than 1 μM (blue circles).