Table 4.

Screening phospholipidosis assay

Drug	Ratio (0.32 μM)	Ratio (15 μM)
Allopurinol	0.13	0.37
Amisulpride	0.08	0.08
Atropine	0.04	0.16
Azaperone	0.16	0.43
Benztropine	0.13	0.68
Benzbromarone	0	0.5
18 Beta-glycyrrhetinic acid	0.16	0.4
Butenafine	0.16	0.31
Carbamazepine	0.12	0.18
Clofazimine	0.11	0.15
Clonidine	0.18	0.25
Clomifene	0.09	0.38
Cloricromen	0.1	0.1
Conessin	0.01	1.08
Corticosterone	0.12	0.28
Desloratadine	0.14	1.13
Diclofenac	0.22	0.49
5,7 Dichloro-8-hydroxy-2-methyl quinolone	0.17	0.29
Dilazep	0.37	1.17
1,7-Dimethylxanthine	0.16	0.55
Disopyramide	0.16	0.57
Encainide	0.09	0.23
Fosinopropil	0.18	0.67
Fosinoprilat	0.07	0.19
Fenspiride	0.07	0.07
Fulvestrant	0.2	0.37
Fuscidic acid	0.13	0.23
Gabapentin	0.07	0.25
Harmine	0	0.11
Hydrocortisone	0.12	0.15
6-Hydroxydopamine	0.2	0.93
3-Hydroxytyramine hydrochloride	0.14	0.91
Hydralazine	0.1	0.6
Imiquimod	0.07	0.07
Isoxsuprine	0.16	1.22
Lidocaine	0.16	0.45
Mebhydrolin	0.12	2.54
Meclofenamic acid	0.18	0.52
S-methylisothiourea	0.15	0.38
Melatonin	0.15	0.26
Mibefradil	0.02	1.21
Naproxen	0.07	0.07
Orphenadrine	0.17	0.29
Paroxetine	0.03	1.11
Penfluridol	0.01	0.55
Phenytoin	0.23	0.38
Pipamperone	0.17	0.37
pp 06424439	0.15	0.21
Prochlorperazine	0.16	0.81
Procyclidine	0.16	1.14
Quinine	0.12	0.34
Ritanserin	0.07	0.19
Rolipram	0.11	0.19
sb222200	0.03	0.34
Suloctidil	0.14	0.66
Trifluoperazine	0.24	0.81
Xylometazoline	0.14	0.16
Amiodarone	0.32	1.64

Each compound was assayed at either 32 or 15 μM. The fluorescence ratio denotes LipidTOX Red Phospholipidosis detection (549–615 nm emission) to NucBlue Live detection (410–480 nm emission).