Table 3.
Antiplasmodial activity and cytotoxicity of isolated compounds from selected fractions
| Plant species | Fractions | Compounds | EC50 (μM) | RI | CC50 (μM) | SI | |||
|---|---|---|---|---|---|---|---|---|---|
| Vero | Raw | ||||||||
| Pf3D7 | PfDd2 | Vero | Raw | Pf3D7 (PfDd2) | Pf3D7 (PfDd2) | ||||
| H. afzelii | F4 | 1 | 19.01 ± 0.72 | 16.39 ± 0.52 | 0.86 | > 185.02 | > 185.02 | > 9.73(> 11.29) | > 9.73(> 11.29) |
| 2 | I | I | – | – | – | – | – | ||
| 3 | I | I | – | – | – | – | – | ||
| 4 | I | I | – | – | – | – | – | ||
| 5a | NT | NT | – | NT | NT | – | – | ||
| E. calophylloides | F8 | 6 | 4.27 ± 0.05 | 1.36 ± 0.47 | 0.32 | > 151.52 | > 151.52 | > 35.48(> 111.41) | > 35.48(> 111.41) |
| Reference drugs | Artemisinin | 0.014 ± 0.001 | 0.018 ± 0.003 | 1.26 | NA | NA | – | – | |
| Chloroquine | 0.018 ± 0.002 | 0.449 ± 0.065 | 24.86 | NA | NA | – | – | ||
| Podophyllotoxin | NA | NA | 4.56 ± 0.92 | 1.83 ± 0.22 | – | – | |||
Results are expressed as means ± standard deviation of duplicate experiments
NT not tested; a: This compound wasn’t tested due to the quantity; I inactive, NA not applicable, EC50 50% effective concentration; CC50 50% cytotoxicity concentration, RI resistance index, SI selectivity index