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. 2021 Jun 25;8:657–670. doi: 10.2147/JHC.S316223

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© 2021 Pan et al.

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Log-transformed alpha-fetoprotein (AFP) and des-gamma-carboxyprothrombin (DCP) levels subdivided according to survival status (A), tumour sizes (B), presence of vascular invasion (C), and treatment models (D). Progression-free survival (PFS) (E) and overall survival (OS) (F) curves of grouped hepatocellular carcinoma patients based on pretreatment AFP and DCP. Reference dashed lines were drawn for diagnostic cut-off values for AFP [log(25)] and DCP [log(40)] in corresponding colours (A–D). Group A, AFP≥25 ng/mL, DCP≥40 mAU/mL; Group B, AFP≥25 ng/mL, DCP<40 mAU/mL; Group C, AFP<25 ng/mL, DCP≥40 mAU/mL; Group D, AFP<25 ng/mL, DCP<40 mAU/mL, (E and F). ****P<0.0001 (Wilcoxon rank-sum test).