TABLE 3.

Effect of ECI vs CM Stratified by Disease Location

	Isolated Colonic CD	Ileal-Dominant CD
	HR (95% CI)	HR (95% CI)	Interaction P
Composite endpoint (hospitalization, surgery, complication)*	0.53 (0.33-0.84)	0.77 (0.58-1.04)	0.069
Time to CD-related complication†	0.51 (0.30-0.85)	0.80 (0.58-1.10)	0.035
Time to surgery‡	0.52 (0.19-1.42)	0.74 (0.53-1.04)	0.468
Time to hospitalization§	0.75 (0.42-1.34)	0.82 (0.67-0.99)	0.788
12 month steroid-free remission¶	1.04 (0.54-2.02)	0.81 (0.55-1.20)	0.429
24 month steroid-free remission‖	0.97 (0.85-1.10)	1.10 (1.00-1.21)	0.070

All analyses adjusted for country, practice size, and clustering effect of practice. Additional adjustments made for individual outcomes made based on backward model regression. *Adjusted for age, baseline fistula, baseline HBI (continuous), baseline PCS. ^†Adjusted for age, baseline fistula, baseline HBI (continuous), baseline PCS. ^‡Adjusted for baseline fistula, baseline antimetabolite use, baseline PCS, baseline EQ-5D – visual analogue scale (VAS). ^§Adjusted for age, baseline PCS, baseline EQ-5D – VAS. ^¶Adjusted for sex, previous surgery, baseline antimetabolite use, baseline PCS, baseline MCS. ^‖Adjusted for sex, disease duration, previous surgery, baseline TNF-antagonist use, baseline PCS, baseline MCS. Baseline remission forced into steroid-free remission models.