TABLE 4.
Within-group difference at 1 y compared with baseline for the EPA+DHA and control groups1
| EPA+DHA | Control | |||||
|---|---|---|---|---|---|---|
| Cognitive test | Mean difference | 95% CI | P value | Mean difference | 95% CI | P value |
| COWAT 1 | 0.8 ± 4.6 | 0.01, 1.6 | 0.047 | 0.08 ± 4.5 | −0.7, 0.9 | 0.83 |
| COWAT 2 | −0.02 ± 5.2 | −0.9, 0.9 | 0.95 | −0.3 ± 4.9 | −1.1, 0.6 | 0.51 |
| DSST | 2.7 ± 7.4 | 1.4, 3.9 | <0.001 | 1.0 ± 9.3 | −0.6, 2.6 | 0.23 |
| TMT A2 | −2.2 ± 11.8 | −4.1, −0.2 | 0.033 | 0.6 ± 13.0 | −1.7, 2.9 | 0.59 |
| TMT B2 | −2.4 | — | <0.001 | −1.0 | — | 0.48 |
| RAVLT1 | 0.7 ± 4.8 | −0.1, 1.5 | 0.068 | 2.0 ± 5.0 | 1.1, 2.9 | <0.001 |
| RAVLT2 | 0.5 ± 2.0 | 0.2, 0.8 | 0.005 | 0.8 ± 2.1 | 0.4, 1.1 | <0.001 |
| RAVLT3 | 0.7 ± 2.1 | 0.3, 1.0 | <0.001 | 1.0 ± 1.9 | 0.6, 1.3 | <0.001 |
| RAVLT4 | 0.1 ± 1.5 | −0.2, 0.4 | 0.44 | 0.4 ± 1.6 | 0.1, 0.7 | 0.006 |
1
Values are mean ± SD. Normally distributed variables were compared using paired t tests except for TMT B which was compared with Wilcoxon's signed-rank test owing to data being nonnormally distributed. Therefore, a median difference was calculated, but a 95% CI could not be generated. COWAT, Controlled Oral Word Association Test; DSST, Digit-Symbol Substitution Test; RAVLT, Rey Auditory Verbal Learning Test; RAVLT1, immediate recall as a sum of 4 trials; RAVLT2, short delay recall; RAVLT3, delayed recall; RAVLT4, delayed recognition; TMT, Trail Making Test.
2
A lower score is better. For all other tests, a higher score is better.